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Du nouveau sur l'interactome des Glycosaminoglycanes

L'équipe de Sylvie Ricard Blum vient de publier un travail sur l'élaboration d'un interactome des glycosaminoglycanes, rassemblant 832 biomolécules et 932 interactions protéines/GAGs

Glycosaminoglycan-Protein Interactions: The First Draft of the Glycosaminoglycan Interactome

This study provides the first comprehensive draft of the GAG interactome  composed  of  832  biomolecules  (827  proteins  and  five  GAGs)  and  932  protein–GAG  interactions. Heparin, heparan sulfate and keratan sulfate have the highest number of specific protein partners, whereas dermatan sulfate has no specific protein partners and the highest percentage of partners able to bind to four or five GAGs. This  network is a scaffold, which in the future should integrate structures of GAG–protein complexes, quantitative data of the abundance of GAGs in tissues to build tissue-specific interactomes, and GAG interactions with metal ions such as calcium, which plays a major role in the assembly of the extracellular matrix and its interactions with cells. This contextualized interactome  will  also be  useful  to  identify  druggable  GAG–protein  interactions  for  therapeutic  purpose.

 

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